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GSK 256066 Trifluoroacetate
CAS No. 1415560-64-3
GSK 256066 Trifluoroacetate ( GSK-256066;GSK256066 (2,2,2-trifluoroacetic acid) )
产品货号. M11725 CAS No. 1415560-64-3
A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥5808 | 有现货 |
|
| 100MG | ￥8060 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK 256066 Trifluoroacetate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively.
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产品描述A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively; displays >380,000-fold selectivity over PDE1/23/5/6/7; inhibits TNFα production by lLPS-stimulated human peripheral blood monocytes with IC50 of 0.01 nM; inhibites LPS-induced pulmonary neutrophilia with ED50 of 1.1 ug/kg (aqueous suspension) and 2.9 ug/kg (dry powder formulation) in rats.COPD Phase 2 Discontinued
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同义词GSK-256066;GSK256066 (2,2,2-trifluoroacetic acid)
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Inflammation/Immunology
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适应症COPD
化学信息
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CAS Number1415560-64-3
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分子量632.61
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分子式C29H27F3N4O7S
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C.C(=O)(C(F)(F)F)O
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化学全称3-Quinolinecarboxamide, 6-[[3-[(dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-, 2,2,2-trifluoroacetate (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Woodrow MD, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5261-5.
2. Tralau-Stewart CJ, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):145-54.
3. Nials AT, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):137-44.
2. Tralau-Stewart CJ, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):145-54.
3. Nials AT, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):137-44.
产品手册
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